Short Peptides and Polypeptides in Sports Nutrition: Which to Choose?

Introduction to Peptides in Sports Nutrition

Peptides are a popular component used in sports nutrition systems for both amateur and professional athlete preparation. All peptides used in sports nutrition can be categorized into two groups: short (small) peptides and polypeptides (larger peptides). Peptides consist of simple components—amino acids. A peptide with a small number of amino acids, such as 3 or 4, is considered a short peptide. If a peptide contains 20-30 or more amino acids, it is classified as a polypeptide. Polypeptides are almost identical to proteins, which are crucial molecules for our body. So why is the distinction between short peptides and polypeptides important? A peptide’s length affects its function, effectiveness, and safety when used in sports nutrition.

The Drawbacks of Polypeptides

Currently, polypeptides are popular in sports nutrition for their fat-burning capabilities, muscle mass growth stimulation, immunity enhancement, and overall well-being improvement. However, polypeptides have significant drawbacks. Particularly, peptide hormones among polypeptides can be incompatible with each other and disrupt the body’s natural hormone production. Moreover, all larger peptides are foreign to the body and can cause allergic reactions. The high physical demands placed on an athlete’s body can often reduce immunity, exacerbating potential allergic reactions from polypeptide use. Polypeptides, often derived from animal sources, can contain harmful impurities such as foreign proteins, DNA fragments, viruses, and prions if purification processes are compromised. These impurities are immunogenic (capable of causing allergies) and can lead to diseases.

Is it possible to retain the beneficial bioregulatory properties of polypeptides while eliminating their drawbacks?

Yes, this has become possible through years of scientific research. It has been discovered that each polypeptide has an active center—a small part responsible for the peptide’s function. By analyzing the composition of polypeptides using special technology, Ideal Pharma Peptide has created short peptides consisting of 2, 3, or 4 amino acid residues. These short peptides do not need to be derived from animal tissues and can be synthesized, which is safer as they will not contain allergenic components.

Benefits of Short Peptides in Sports Nutrition

The advantage of innovative short peptides is that they are structurally identical to the natural active (functional) centers of polypeptide molecules and are not perceived as foreign substances by the body. It’s important to note that Ideal Pharma Peptide’s short peptides, essentially serving as the “function” of the polypeptide molecule, are used in sports nutrition in lower concentrations than larger peptides.

Another significant advantage of Ideal Pharma Peptide’s short peptides is their better absorption by the body compared to polypeptides. Proteins and polypeptides ingested with food enter the stomach and intestines, where they are “cut” into smaller fragments—short peptides consisting of 2 or 3 amino acid residues—by specific enzymes (peptidases). These short peptides then enter the bloodstream and are transported to muscles and other organs and tissues, where they exert a regulatory effect.

Ideal Pharma Peptide: Leading the Way in Peptide Innovation

Ideal Pharma Peptide is a global innovator in the production of short peptides. The company has developed a series of short peptides named IPH and SNL for the food, cosmetic, and sports industries. These peptides stimulate the nervous, immune, and endocrine systems, have antioxidant properties, activate metabolism, and are used for cancer prevention and life extension. Notably, the exact mechanism of biological activity is not always known for polypeptides, whereas for IPH and SNL short peptides, such research is much simpler, allowing for a precise understanding of the peptide’s action mechanism. This ensures confidence in the effectiveness and safety of Ideal Pharma Peptide’s (Germany) IPH and SNL short peptides.

Thus, IPH and SNL short peptides, possessing all the biological effects of polypeptides, are safe, non-immunogenic, have a scientifically substantiated mechanism of action, and are the best solution as components of sports nutrition and as a development vector in modern pharmacology and molecular medicine.

Sources Confirming the Efficacy and Safety of Short Peptides

1. Ashapkin V.V., Linkova N.S., Khavinson V.Kh., Vanyushin B.F. Epigenetic Mechanisms of Peptidergic Regulation of Gene Expression in Human Cell Aging // Biochemistry. – 2015. – Vol. 80, Issue 3. – Pp. 374-388.
2. Zilova I.S. Protein Components in Specialized Food Products for Athlete Nutrition // Nutrition Issues. – 2014. – Vol. 83, No. 53. – P. 133.
3. Mezenova N.Yu., Vertukhov V.V., Volkov V.V., Baydalinova L.S., Mezenova O.Ya. Determination of Technological Indicators of Active Peptide Powders from Fish Scales in a Bioproduct for Sports Nutrition // University News. Applied Chemistry and Biotechnology. – 2016. – No. 2 (17). – Pp. 104-114.
4. Khavinson V.Kh., Trofimova S.V., Trofimov A.V., Kachan Y.Y., Viner-Usmanova I.A., Terekhina R.N., Kryuchek E.S., Pirozhkova E.A. Methods to Improve the Preparedness Level of High-Class Gymnasts Based on the Use of Special Physical Training and Peptide Bioregulators. // Methodical Recommendations. – St. Petersburg: St. Petersburg Institute of Bioregulation and Gerontology. – 2013. – 44 p.
5. Khavinson V. Kh., Polyakova V. O., Linkova N. S., Dudkov A. V., Kvetnoy I. M. Peptides Regulate Differentiation, Proliferation, and Apoptosis of Cortical Thymocytes // Journal of Amino Acids. 2011. Article ID 517137. P. 1-5.
6. Khavinson V.Kh., Tendler S.M., Rfsyanenko N.a., Tarnovskaya S.I., Linkova N.S., Ashapkin V.V., Yakutseni P.P., Vanyushin B.F. The Tetrapeptide KEDW Interacts with DNA and Regulates Gene Expression // American Journal of Biomedical Sciences. – 2015. – Vol. 7, N3. – P. 156-169.
7. Khavinson V.Kh., Tendler S.M., Vanyushin B.F., Kasyanenko N.A., Kvetnoy I.M., Linkova n.S., Ashapkin V.V., Polyakova V.O., Basharina V.S., Bernaotte A. Peptide Regulation of Gene Expression and Protein Synthesis in Bronchial Epithelium // Lung. – 2014. – Vol. 192. – P. 781-791.
8. Medvedeva E.V., Dmitrieva V.G., Povarova O.V., Limborska S.A., Skvortsova V.I., Myasoedov N.F., Dergunova L.V. The Peptide Semax Affects the Expression of Genes Related to the Immune and Vascular Systems in Rat Brain Focal Ischemia: Genome-wide Transcriptional Analysis // BMC Genomics. – 2014. – Vol. 15. – P. 228.
9. Stadnik J., Kęska P. Meat and fermented meat products as a source of bioactive peptides // Acta Sci Pol .Technol . Aliment. — 2015. — Vol. 14, N 3. — P. 181-190.
10. Sweetwyne M.T., Pippin J.W., Eng D.G., Hudkins K.L., Chiao Y.A., Campbell M.D., Marcinek D.J., Alpers C.E., Szeto H.H., Rabinovitch P.S., Shankland S.J. The mitochondrial-targeted peptide, SS-31, improves glomerular architecture in mice of advanced age //Kidney Int. 2017. S0085-2538(16)30652-4.