Peptides by Khavinson

All our peptides, which I call Khavinson peptides, have a distinguishing feature compared to other peptides. Khavinson peptides are substances that regulate specific genes. What is aging? Aging is a reduction in gene activity and protein synthesis. Genes control protein synthesis, and when protein synthesis decreases, organ functions decline, leading to various diseases or aging. Therefore, when we activate genes, protein synthesis increases, tissue and organ function improve, and the organism becomes more efficient and lives longer. This is the general formula of life, so to speak, where peptides, genes, and aging are interconnected.

In the past, Khavinson faced criticism because experiments proving that groups of mice taking peptides lived on average 40% longer were seen as applicable only to mice. However, human studies were also conducted, and they involved a group of people over an extended period.

“When we conducted the research on humans, we carried out 15 years of clinical trials in two places. One of these places was the Gerontology Institute of the National Academy of Medical Sciences of Ukraine, in collaboration with Academician Oleg Vasilievich Korkushko, who is now 83 years old. We began this work in Kiev, established a brilliant clinic, selected people with an average age of 65 years, and administered thymus and pineal peptides to them twice a year, among others. All of this was recorded in their medical histories, and they were admitted to the clinic for a whole month, where they underwent examinations and received these treatment courses twice a year. After 15 years, we found that the people who received the peptides had a 50% reduction in mortality compared to the control group,” explained Khavinson.

Oleg Korkushko, a corresponding member of the National Academy of Medical Sciences of Ukraine and the head of the therapeutic department at the Institute of Gerontology of the National Academy of Medical Sciences of Ukraine, added, “In the 1990s, we met Khavinson in 1991 when he came to our institute and presented his views. Since we work in this field, we decided to conduct this research. We did not even expect this effect – that peptides have a positive impact and increase the survival rate of people with accelerated aging, particularly ischemic heart disease. Despite standard therapy, the second group that did not receive peptides showed a 38-40% difference in survival over 15 years.”

Today, peptide regulators are successfully used in gerontology. Initially, they were developed at the Military Medical Academy as drugs to enhance the body’s resources and improve the combat readiness of servicemen operating in extreme conditions. Consequently, they were suitable for professional athletes. It’s no surprise that coaches of Olympic champions turned to Khavinson for help.

“In the past, Irina Alexandrovna Viner-Usmanova, the head coach and president of the Federation of Rhythmic Gymnastics, approached us with a request to help her athletes. These young girls had various health problems despite their young age. When we examined them, we were surprised to find that their bodies were aging rapidly. After conducting diagnostics, genetics, and measuring telomere lengths, we administered a complex of peptides, including brain, immune system, cartilage, and vascular peptides. We achieved a complete restoration of all their functions, normalization. This was done before the London Olympics. We managed to increase their activity and resistance so much that none of them fell ill, and they all performed excellently. They won three gold medals. This is an example. Therefore, peptide drugs are necessary for anyone experiencing stressful situations,” said Khavinson.

Vladimir Khavinson has always been ready to change the world for the better through peptides, science, and the promotion of domestic medical developments. His colleagues also note his remarkable work capacity and his ability to achieve his goals, not for commercial interests, but to demonstrate the uniqueness of his drugs.

Evgeny Shlyakhto, the Director-General of the Federal State Budgetary Institution “North-Western Federal Medical Research Center named after V.A. Almazov,” recalled Vladimir Khavinson’s early career: “I remember him when we were young. He was already well-known in the Military Medical Academy for his work in biochemistry and leading research related to the development of these new peptide drugs. It might not have been easy to promote and develop all of this. But as the years and decades passed, it has been preserved and developed. So, I can say that it is very important that he remains true to the direction he chose and continues to develop it with determination.”

Boris Vanyushin, a corresponding member of the Russian Academy of Sciences and the head of the Molecular Bases of Ontogenesis Department at the Institute of Physico-Chemical Biology named after A.N. Belozersky, shared his experience working with Khavinson: “We met at a symposium far from here in Syktyvkar. Someone came up to the podium and talked about how these peptides could have a physiological effect and that their action was associated with specific interactions with DNA. After his presentation, I approached him. This was only a few years ago. I said, ‘Vladimir, I have DNA and enzymes. If they interact with your peptides, could they regulate the activity of specific enzymes? Give me your peptides!’ He gave me his peptides, and as an independent person working at Moscow State University, I tried them out. It turned out that his short peptides do indeed control the actions of many important enzymes, particularly nucleases. We jointly published our work. It has been productive because many people were initially skeptical about this, as I was, but after I and my colleagues carefully conducted experiments, we saw that the expression of tissue-specific responsible genes that control cell differentiation significantly changed in cell cultures under the influence of his peptides. It was hard to believe at first, but the fact remains.”

Yuri Gulyaev, an academician of the Russian Academy of Sciences and the chairman of the subcommittee on communications and informatics of the Supreme Soviet of the USSR from 1989 to 1991, described Khavinson as an excellent scientist and organizer: “Khavinson is a scientist in his field, a remarkable organizer. I can tell you that he is a very good person. A kind, gentle person, as a doctor and specialist should be when it comes to their specific profession.”

Elena Korneva, an academician of the Russian Academy of Sciences and the head of the Department of General Pathology and Pathological Physiology at the Federal State Budgetary Institution “N.I. Pirogov Russian National Research Medical University,” mentioned her long-standing familiarity with Vladimir Khavinson: “I’ve known Khavinson since childhood, practically from his student years and the beginning of his career. He has always been involved in gerontology and substances that can influence the aging process. He is a very passionate person, always interested in what he does. We examined to some extent the spectrum of action of the substances he proposed, which are low-molecular-weight peptides, and we studied their effects on the nervous and immune systems. They turned out to be quite effective, even though people often say that the mechanisms are unknown. There are many things in the world that are not understood, but what is, is. We saw it work with our own eyes.”

Yuri Yanov, a corresponding member of the Russian Academy of Sciences and the director of the Federal State Budgetary Institution “St. Petersburg Research Institute of Ear, Throat, Nose, and Speech,” shared his memories of Khavinson from their early years: “I’ve known Khavinson since 1966 when I entered the Military Medical Academy. He was already in his second year there. From a young age, during his second year, he was already involved in physiology and immunology issues and achieved such great success that we can now be proud of him. St. Petersburg and Russia can be proud of the achievements Vladimir Khavinson has made.”

Alexander Grinenko, an academician of the Russian Academy of Sciences and the chairman of the Healthcare Committee of the Leningrad Region from 1987 to 2007, described Khavinson as a person charged with research and results who blazes new trails with his character, skills, and knowledge, achieving remarkable accomplishments.

Vladimir Khavinson’s St. Petersburg Institute of Bioregulation and Gerontology has been involved in developing methods for preventing and correcting age-related pathologies for 23 years. The introduction of peptides into medical practice has contributed to the establishment of bioregulatory therapy, which involves the comprehensive use of peptide drugs for both treatment and prevention of diseases.

Svetlana Trofimova, the deputy director of the St. Petersburg Institute of Bioregulation and Gerontology and the director of the “Tree of Life” Medical Center, emphasized the importance of the comprehensive approach to treatment and prevention using peptide drugs.

Zoya Zabalueva, a patient at the ophthalmology department, shared her experience with the treatment: “I came here with macular degeneration of the retina, where the central part of the retina dies. Cells die off, forming scotomas. Here, they stopped the deterioration process, or rather, completely halted it, and my vision stopped deteriorating. I undergo a course of injections where drugs are administered intramuscularly into the temples. These drugs stimulate the production of your own stem cells. This allows the regeneration process to become, presumably, as powerful as the cell death process. Thanks to this, the process is halted, and these drugs remain active in the body for six months. People here are focused on results and making patients better or at least not worse in terms of their condition.”

Yulia Osokina, the head of the Ophthalmology Department at the St. Petersburg Institute of Bioregulation and Gerontology, explained the institute’s focus on treating degenerative retinal diseases. She mentioned that their specialty involves conditions where improvement cannot be achieved through surgery or other therapies. The peptides developed by Khavinson’s team can halt these degenerative processes and even reverse them, which is an accomplishment that has been difficult to achieve elsewhere. Patients come to them for years, and with the right treatment courses, they can stop processes that would otherwise lead to inevitable blindness, allowing patients to maintain or even improve their vision.

Ophthalmology is one of the primary fields of work at the St. Petersburg Institute of Bioregulation and Gerontology. Still, peptides based on Khavinson’s research have been used to address a wide range of medical conditions. One of the advantages of peptide-based treatments is that they don’t generate antibodies in the human body, which means that medications created from them generally do not produce side effects. While many have attempted to research this field, the St. Petersburg Institute of Bioregulation and Gerontology has achieved true success.

Yulia Steblyanko, a scientific researcher at the institute, mentioned an ongoing project in which they are testing new peptides synthesized by them, similar to endogenous peptides extracted from the human body. They will evaluate how these peptides can stimulate tissue regeneration, differentiation, and cell proliferation in various human tissues. They hope to obtain excellent results, which will allow them to work on patents for these peptides and eventually introduce them into medical practice.

Peptide bioregulators help the body to self-repair. Over many years, their use in healthcare has demonstrated their high effectiveness compared to other pharmaceutical substances. When it comes to extending a person’s active age, Khavinson’s developments are considered groundbreaking. During the institute’s existence, its specialists have created over 40 geroprotective drugs protected by 180 patents in Russia, the USA, Japan, and other countries.

Elvira Plotnikova, the Assistant Director for Intellectual Property at the St. Petersburg Institute of Bioregulation and Gerontology, mentioned that they have more than 20 Eurasian patents covering countries like Kazakhstan, Kyrgyzstan, Moldova, Armenia, Azerbaijan, Turkmenistan, as well as patents in the European Union, the United States, Canada, Australia, Japan, and South Korea. Patents are valid for 20 years, providing them with priority in various areas.

Olga Mikhailova, the Deputy Director General of the St. Petersburg Institute of Bioregulation and Gerontology, highlighted their significant achievements over the years. One notable achievement was the creation of an encyclopedia on gerontology initiated by Vladimir Khavinson in Europe. This project aimed to advance gerontology in Europe and promote international collaboration among scientists, exchanging experiences, opinions, and data on a broad scale. It’s essential to communicate these findings to political circles because global demographic trends are heading toward an aging population. Aging has been accelerating rapidly in developing and transition economies, including Russia. Vladimir Khavinson plays a crucial role in bridging the gap between science and politics.

Khavinson’s peptides, as supported by scientific research, slow down the aging process and increase the average lifespan. Cells typically divide around 50 times, but the introduction of bioregulators into the body can increase the number of divisions to 60-65, significantly extending their lifespan. Those who are aware of this secret often prefer to personally consult with Professor Khavinson. The institute attracts a diverse range of guests and patients, from Arab sheikhs to well-known artists.

The St. Petersburg Institute of Bioregulation and Gerontology has attracted a wide range of visitors and patients, including prominent figures from various fields. Here are some notable individuals who have visited or sought treatment at the institute:

1. Prime Minister of Thailand, Thaksin Chinawat: He offered to build a facility for the institute in Bangkok due to his support for anti-aging research.
2. Governor of St. Petersburg: Awarded a distinguished scientist of the Russian Federation award, signed by the President of Russia.
3. Minister of Energy of the United Arab Emirates: Sheikh Said visited the institute and proposed moving it to Abu Dhabi, although this was not pursued due to extreme temperatures.
4. Professor Cha, President of the World Association of Gerontology and Geriatrics from South Korea, visited St. Petersburg and the institute.
5. Rem Ivanovich Vyakhirev, President of Gazprom, was both a visitor and patient of the institute for some time.
6. President of Bosphorus Gas (a subsidiary of Gazprom in Turkey): Supported the institute’s research.
7. Boris Ivanovich Alferov, Vice President of the Russian Academy of Sciences and Nobel laureate, supported the institute’s research.
8. President of Kazakhstan: He visited the institute and expressed strong support for its research.
9. Nobel laureate from Belgium: Visited the institute.
10. Nobel laureates Dogterom and Zinkernagel: Signed a book for Vladimir Khavinson.

The institute has also received visits from individuals in the field of culture, including Valery Leontiev, Mikhail Zadornov, Igor Kornelyuk, and cosmonaut Alexander Grechko, all of whom have sought assistance from the institute.

Despite the presence of various approaches to anti-aging and health in the world, many individuals still choose to visit and seek treatment from Vladimir Khavinson and the St. Petersburg Institute of Bioregulation and Gerontology, underscoring the effectiveness and reputation of their research in the field of gerontology.