Alteration of Protein Expression
With the advent of peptide complexes, it was proven that protein expression can be altered. Positive trends in the activation of the body’s reserve capabilities are recorded as a result. Peptide bioregulators also suppress the expression of specific genes, which can even lead to a reduction in tumorous processes.
It has been shown that the application of peptide complexes positively changes the results of biochemical research. For example, consider a study in which two groups of female athletes were selected. Physical loads were the same for all. However, peptide complexes were used only in the main group, while the second group did without them.
This experiment allowed us to determine how much protein expression increases with the use of peptide bioregulators. When evaluating the main group’s physical performance, muscle energy supply levels, and fitness, these values increased by an average of 10–15 percent. There was no improvement in the control group (those not using the supplements).
The athletes who took peptides showed an increase in the body’s reserve capabilities and achieved higher athletic results. This was confirmed by the results of PRAGS and PPARA gene expression. The average values of both groups are presented in Table 1.
Table 1.
| Genes |
Main |
Control |
| Before Peptide Intake |
After Supplement Use |
First Measurement |
| PRAGS |
0.17 ± 0.08 |
3.86 ± 0.36 |
| PPARA |
1.81 ± 0.12 |
4.53 ± 0.14 |
| HSPAlA |
111.67 ± 9.4 |
328.9 ± 15.8 |
The data indicate an increase in expression under the influence of peptide bioregulators. HSPAlA programs the synthesis of heat shock proteins (70 kDa-HSP-70), and the other two genes increase the oxidative abilities of skeletal muscle. Heat shock proteins are among the main markers triggering adaptive processes in the cell, responding to stress.
The increase in the value of HSP-70 suggests that protective processes in leukocytes have been activated, helping to maintain and enhance protein neosynthesis, prevent folding, and disruptions caused by stress and intense physical exertion. The first two genes in the table encode proteins capable of binding to PPAR elements in gene promoters, which strongly influence carbohydrate and lipid metabolic processes and adjust their transcription.
The increase in PRAGS and PPARA expression and genes under their control enhances the oxidative abilities of muscles and increases their performance. Muscle fatigue is significantly reduced in this process. In the control group, there was no significant increase in values, and there was a tendency to slow down HSPAlA expression. Therefore, the use of peptide bioregulators led to an improvement in the health of the main group’s athletes.
Impact of Peptide Complexes on Blood Biochemical Research Results
Additionally, biochemical research was conducted, which documented a decrease in bilirubin levels in the main group. It also recorded a decrease in the amount of lactic acid in the blood, observed in the main group. This occurred due to improved energy metabolism after the effects of dietary supplements. The impact of peptides can be assessed based on the results of biochemical research (data in Table 2).
Table 2
| Parameters |
Normal Values |
Control Group |
Main Group |
| Bilirubin |
Not more than 22.2 |
12.6 ± 1.3 |
16.2 ± 1.4 |
| Total Protein |
66–87 |
77.3 ± 2.62 |
78.9 ± 2.12 |
| Glucose |
3.6–6.11 |
4.3 ± 0.2 |
4.6 ± 0.3 |
| Cholesterol |
Not more than 5.7 |
4.3 ± 0.71 |
4.2 ± 0.21 |
| Calcium |
2.20–2.55 |
2.31 ± 0.35 |
2.29 ± 0.2 |
| Albumins |
38–51 |
44.3 ± 2.23 |
47.2 ± 1.91 |
| AST |
Not more than 32 |
16.6 ± 2.8 |
19.4 ± 3.2 |
| ALT |
Not higher than 31 |
17.3 ± 1.4 |
16.2 ± 2.1 |
The research results show that peptide bioregulators have a positive impact on processes associated with the normalization and reduction of initial and final products of lipid peroxidation. Such dietary supplements can be recommended to athletes for improving their qualifications. No positive changes in the blood antioxidant defense system were observed in the control group.
The use of peptide complexes can be recommended not only in the field of sports. For example, IPH peptide complexes by Ideal Pharma Peptide allow for improvements in various indicators, positively affecting overall health and quality of life.
However, the use of these supplements is possible only after consulting a doctor. Then the effectiveness of the products will be maximized. By modifying gene expression, proteins can be directed in the right direction for synthesis.
